Around age 13, she signed with Biograph Studios and it only took a few months before she became a rival of Mary Pickford. The had quiet different screen personas though. While Mary was the typical Griffith heroine, demure and virginal, Blanche was gutsy and adventurous. Another rival of hers was Lillian Gish, who won the lead role in Birth of a Nation over Blanche. It was soon after this blow that she left Biograph and moved to Famous Players-Lasky...for way more money it should be noted.
The change in studios didn't hinder her career because she continued to be an audience favorite. And even better, the critics thought she was great too!
Blanche was married twice. Her first husband was director/producer, Marshall Neilan. The two began an affair during the 1920s while he was married to actress, Gertrude Bambrick. When Gertrude found out about the affair, she filed for divorce from Neilan. Blanche and he married in 1922, but divorced in 1929 because he just could not stop cheating.
Her second marriage was to actor Raymond Hackett in 1935. The marriage lasted until his death in 1958. Neither marriage resulted in children.
When she was touring and staying at hotels, she would check in using the name "Daphne Wayne."